Upper GI Lab
Flinders Upper Gastrointestinal Research Group
Head of Upper GI Research Group: Dr Damian Hussey
Phone: +61 8 8204 6091
The Upper GI Research Group, located within the Flinders Department of Surgery, undertakes research into diseases of the oesophagus and stomach.
These studies use gene expression profiling to understand and predict the behaviour of pre-cancerous and cancerous lesions in the oesophagus, with a particularly strong focus on the family of genes called microRNAs (miRNAs).
miRNA molecules bind to messenger RNA (mRNA) molecules that produce proteins, and thereby interfere with the production of protein in cells. By acting in this way, miRNAs are key regulators of gene expression and cellular behaviour and are useful biomarkers for studying disease.
By identifying relevant miRNAs, we are exploring the expression of the mRNAs that they regulate, and to identify biological pathways that are affected by the miRNAs. Using gene expression profiling to understand and predict the behaviour of pre-cancerous and cancerous lesions are important steps towards cancer control, the longer-term goal of our research.
For more information about the work of the Upper GI Lab Research Group please click on the following links.
Students with a first class Honours degree in the field of molecular and/or cellular biology, or a Medical degree, and with an interest in cancer research, can contact Dr Hussey or Professor David Watson to discuss options for higher degree research studies, including PhD and MS.